1.  loosen up(v = verb.contact) unstuff - cause to become unblocked; "The medicine unstuffed my nose in minutes!"
Sample sentences: Somebody ----s something; Something ----s something

2.  loosen up(v = verb.social) relax - become less tense, less formal, or less restrained, and assume a friendlier manner; "our new colleague relaxed when he saw that we were a friendly group"
Sample sentences: Somebody ----s

3.  loosen up(v = verb.body) limber up, warm up - make one's body limber or suppler by stretching, as if to prepare for strenuous physical activity;
Sample sentences: Somebody ----s

4.  loosen up(v = verb.body) decompress, relax, slow down, unbend, unwind - become less tense, rest, or take one's ease; "He relaxed in the hot tub"; "Let's all relax after a hard day's work"
Sample sentences: Sam and Sue %s

5.  loosen up(v = verb.body) make relaxed, relax, unlax, unstrain, unwind - cause to feel relaxed; "A hot bath always relaxes me"
Sample sentences: The performance is likely to %s Sue